Effect of Aqueous Extract of Passiflora edulis on Oxidative Stress in Liver and Kidney of Alloxan Induced Diabetic Rats

Oxidative stress induced by alloxan is implicated in eliciting pathological changes in diabetes mellitus. This study was undertaken to determine the effect of P. edulis aqueous leaf extract on oral administration at a concentration of 200 mg/kg body weight for 30 days to alloxan treated animals. Liver and kidney were excised and used for biochemical studies like invitro lipid peroxidation, enzymatic antioxidant and non enzymatic antioxidants level.A remarkable increase in the level of enzymatic antioxidants like peroxidase, glutathione peroxidase , superoxide dismutase, catalase , glucose6-phosphate dehydrogenase, polyphenol oxidase and non enzymatic antioxidant like glutathione, vitamin C and vitamin E were observed. Decrease in basal lipid peroxidation, ascorbate and peroxide induced lipid peroxidation in both the organs were also observed.This study indicates that aqueous leaf extract of P. edulis decrease the damage caused by oxidative stress in diabetic rats.